Dr Muki Shey is a Wellcome Trust Intermediate Fellow (in Public Health & Tropical Medicine) and a Chief Research Officer in the Department of Medicine in the Faculty of Health Sciences at the University of Cape Town. Muki is a Principal Investigator and his research group is investigating the immunological and genetics factors contributing to protection against infection with Mycobacterium tuberculosis in healthcare workers with sustained occupational exposure. He is also working as Chief Scientist on HIV and TB projects aimed at understanding the reasons for high mortality in severe HIV-associated TB patients. Muki is currently the lead Scientist for T cell immunology on a COVID-19 Phase 1 vaccine currently recruiting in South Africa. Muki previously worked at Aeras Global TB Vaccine Foundation as a Scientist and Laboratory Manager on clinical trials of novel TB vaccines. Before then he completed a post-doctoral fellowship at the Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal in Durban, South Africa, where his research was focused on understanding the mechanisms of HIV transmission across the female genital tract and prevention strategies including the use of topical microbicides. Muki has also previously consulted for the World Health Organisation (WHO) where he was centrally involved in conducting 2 systematic reviews on the safety and efficacy of BCG vaccine to prevent tuberculosis, as well as conducting policy briefs on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 in the Africa Region.